Concerted action of P450 plus helper protein to form the amino-hydroxy-piperidone moiety of the potent protease inhibitor crocapeptin.

@article{Viehrig2013ConcertedAO,
  title={Concerted action of P450 plus helper protein to form the amino-hydroxy-piperidone moiety of the potent protease inhibitor crocapeptin.},
  author={Konrad Viehrig and Frank Surup and Kirsten Harmrolfs and Rolf Jansen and Brigitte Kunze and Rolf M{\"u}ller},
  journal={Journal of the American Chemical Society},
  year={2013},
  volume={135 45},
  pages={16885-94}
}
The crocapeptins are described here as cyclic depsipeptides, isolated from cultures of the myxobacterium Chondromyces crocatus . Structure elucidation of the compounds revealed a cyanopeptolin-like skeleton, containing the characteristic amino-hydroxy-piperidone (Ahp)-heterocycle. Like the cyanopeptolins, the myxobacterial crocapeptins proved to be serine protease inhibitors. The nonribosomal origin of the peptide was confirmed by mutagenesis experiments, and the biosynthesis gene cluster was… CONTINUE READING

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