Concerted action of Aurora B, Polo and NHK-1 kinases in centromere-specific histone 2A phosphorylation

@inproceedings{Brittle2007ConcertedAO,
  title={Concerted action of Aurora B, Polo and NHK-1 kinases in centromere-specific histone 2A phosphorylation},
  author={Amy L. Brittle and Yasuaki Nanba and Takashi Ito and Hiroyuki Ohkura},
  booktitle={Experimental cell research},
  year={2007}
}
The spatial and temporal control of histone modifications is crucial for precise regulation of chromatin structure and function. Here we report that phosphorylation of H2A at threonine 119 (T119) is enriched at centromere regions in Drosophila mitosis. We found that the Aurora B kinase complex is essential for this phosphorylation at centromeres, while Polo kinase is required to down-regulate H2A phosphorylation on chromosome arms in mitosis. Cyclin B degradation triggers loss of centromeric… CONTINUE READING

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