Concerted Perturbation Observed in a Hub Network in Alzheimer’s Disease

  title={Concerted Perturbation Observed in a Hub Network in Alzheimer’s Disease},
  author={Dapeng Liang and Guangchun Han and Xuemei Feng and Jiya Sun and Yong Duan and Hongxing Lei},
  booktitle={PloS one},
Alzheimer's disease (AD) is a progressive neurodegenerative disease involving the alteration of gene expression at the whole genome level. Genome-wide transcriptional profiling of AD has been conducted by many groups on several relevant brain regions. However, identifying the most critical dys-regulated genes has been challenging. In this work, we addressed this issue by deriving critical genes from perturbed subnetworks. Using a recent microarray dataset on six brain regions, we applied a… CONTINUE READING
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