Concerted Nucleophilic Aromatic Substitutions

  title={Concerted Nucleophilic Aromatic Substitutions},
  author={Eugene E. Kwan and Yuwen Zeng and Harrison A Besser and Eric N. Jacobsen},
  journal={Nature chemistry},
  pages={917 - 923}
AbstractNucleophilic aromatic substitution (SNAr) is one of the most widely applied reaction classes in pharmaceutical and chemical research, providing a broadly useful platform for the modification of aromatic ring scaffolds. The generally accepted mechanism for SNAr reactions involves a two-step addition–elimination sequence via a discrete, non-aromatic Meisenheimer complex. Here we use 12C/13C kinetic isotope effect (KIE) studies and computational analyses to provide evidence that… 
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