Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

@article{Remus2009ConcertedLO,
  title={Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing},
  author={Dirk Remus and Fabienne Beuron and G{\"o}khan Tolun and Jack D. Griffith and Edward Patrick Morris and John F X Diffley},
  journal={Cell},
  year={2009},
  volume={139},
  pages={719-730}
}
The licensing of eukaryotic DNA replication origins, which ensures once-per-cell-cycle replication, involves the loading of six related minichromosome maintenance proteins (Mcm2-7) into prereplicative complexes (pre-RCs). Mcm2-7 forms the core of the replicative DNA helicase, which is inactive in the pre-RC. The loading of Mcm2-7 onto DNA requires the… CONTINUE READING