Concerted Action of Androgens and Mechanical Strain Shifts Bone Metabolism from High Turnover into an Osteoanabolic Mode

Abstract

Adhesion of bone cells to the extracellular matrix is a crucial requirement for osteoblastic development and function. Adhesion receptors connect the extracellular matrix with the cyto-skeleton and convey matrix deformation into the cell. We tested the hypothesis that sex hormones modulate mechanoperception of human osteoblastic cells (HOB) by affecting… (More)

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Cite this paper

@article{Liegibel2002ConcertedAO, title={Concerted Action of Androgens and Mechanical Strain Shifts Bone Metabolism from High Turnover into an Osteoanabolic Mode}, author={Ute Monika Liegibel and Ulrike Sommer and Pascal Tomakidi and Ulrike Hilscher and Loes van den Heuvel and Rainer Pirzer and Joachim Hillmeier and Peter P Nawroth and Christian H. Kasperk}, journal={The Journal of Experimental Medicine}, year={2002}, volume={196}, pages={1387 - 1392} }