Concerning the Proposed Existence of a One-iron–Protein Species of Conalbumin or Siderophilin

THE iron-binding proteins siderophilin (transferrin) from human blood plasma and conalbumin, an analogous protein from hen's egg white, are known to bind firmly two ferric ions per protein molecule1,2. Controversy exists as to whether the two iron-binding sites show positive interaction leading to all-or-none binding of iron3–5, or show equal and… CONTINUE READING