Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

@article{Boveri2008ConcerningTO,
  title={Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris},
  author={Th. Boveri},
  journal={Journal of Cell Science},
  year={2008},
  volume={121},
  pages={1 - 84}
}
  • Th. Boveri
  • Published 1 January 2008
  • Biology, Medicine
  • Journal of Cell Science
In the year 1902, I tacked onto the results of my experiments on the development of doubly fertilised sea urchin eggs the speculation that malignant tumours might be the consequence of a certain abnormal chromosome constitution, which in some circumstances can be generated by multipolar mitoses ([ 
Boveri at 100: cancer evolution, from preneoplasia to malignancy
  • N. Wright
  • Biology, Medicine
    The Journal of pathology
  • 2014
TLDR
Modern researchers rarely refer to this paper, yet as a source of ideas it must rank amongst the landmarks in tumour biology of the last 100 years.
Boveri at 100: Theodor Boveri and genetic predisposition to cancer
TLDR
His contributions to the understanding of hereditary cancers, which, alongside the astute clinical observations of Paul Broca and Aldred Scott Warthin, were published decades before the field became respectable, yet could still inform anyone studying hereditary cancers.
The shock of being united and symphiliosis
TLDR
A lesson from plant evolution, in which an accidental increase in ploidy has a prevalent role, suggests that this assumption that how neoplastic cells become polyploid is irrelevant needs to be reconsidered.
Boveri at 100: Boveri, chromosomes and cancer
  • S. Heim
  • Biology, Medicine
    The Journal of pathology
  • 2014
TLDR
In the future, one may expect cancer cytogenetics to focus not only on how the various aberrations contribute to tumourigenesis, but also on why and how they occur, as well as on the biological meaning behind the polyclonality detected in several epithelial neoplasms.
Singling Out Chromosome Gains in Tumor Evolution.
In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress
Tumor aneuploidy correlates with hallmarks of cancer
TLDR
This work has shown that cellular aneuploidy is a driving force in the process of carcinogenesis and its role in tumorigenesis is underlined by its association with elevated cellular DNA content in several types of cancers.
Historical Landmarks in an Understanding of the Lymphomas
TLDR
This chapter describes this sequence of events and details the progression of discoveries that have led to the modern concept of lymphoma, its classification, and therapeutic advances.
A Bacterial Cause of Cancer: An Historical Essay.
TLDR
The history of the discovery of microbes that increase the risk of cancer of some tissues is reviewed with a special emphasis on the bacterium Helicobacter pylori and the role played by two Australian physicians who had open minds about the shibboleth that mycobacteria can survive the acid environment of the stomach, but that other pathogenic bacteria cannot.
PTEN: History of a Tumor Suppressor.
  • L. Salmena
  • Biology, Medicine
    Methods in molecular biology
  • 2016
TLDR
This introductory chapter provides a historical perspective on current understanding of PTEN including some of the seminal discoveries in the tumor suppressor field, the events leading to PTEN's discovery, and an introduction to some the most important researchers and their studies which have shed light on PTEN biology and function as the authors know it today.
Revisiting tumour aneuploidy — the place of ploidy assessment in the molecular era
TLDR
This hypothesis that aneuploidy in cancer tissue has been implicated as a predictor of a poor prognosis is explored by surveying the current landscape of peer-reviewed research in which DNA cytometry has been applied in studies with disease-appropriate clinical follow up and placing particular emphasis on results from multivariate analyses.
...
1
2
3
4
5
...

References

SHOWING 1-2 OF 2 REFERENCES
Studien Über Entwicklungsanomalien bei Ascaris
TLDR
Inhaltsfibersicht, Sei?~e Vorbemerkung; Die Entwicklung yon Eiern mit atypischem Chromatingehal t; Die St ruktur des A s c a r i s E i e s.
über das Auseinandergehen von Furchungs- und Gewebezellen in kalkfreiem Medium
  • C. Herbst
  • Chemistry
    Archiv für Entwicklungsmechanik der Organismen
  • 2005
Die Thatsachen, welche ich im Folgenden der Offentlichkeit iiberg'ebe, sollten ursprtinglich einen Abschnitt des zweiten Theiles meiner umfang'reichen Untersuehungen, tiber die zur Entwiekelung der