Concepts of the last eukaryotic common ancestor

  title={Concepts of the last eukaryotic common ancestor},
  author={Maureen A O'Malley and Michelle M. Leger and Jeremy G. Wideman and I. Ruiz-Trillo},
  journal={Nature Ecology \& Evolution},
Insight into the last eukaryotic common ancestor (LECA) is central to any phylogeny-based reconstruction of early eukaryotic evolution. [...] Key Method Here the authors examine four potential forms of LECA: an abstract phylogenetic state, a single cell, a population, and a consortium of organisms.Expand
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  • D. Devos
  • Medicine
  • Molecular biology and evolution
  • 2021
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Genetic and genomic evolution of sexual reproduction: echoes from LECA to the fungal kingdom.
It is hypothesized that several critical processes in sexual reproduction were acquired during the evolution from the first eukaryotic common ancestor (FECA) to the sexual LECA, and that cell-cell fusion, meiosis, and sex determination later arose to shape modern sexual reproduction. Expand
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The mechanisms that generate changes along mt-genomes are described, which play key roles at enlarging the ability of fungi to adapt to changing environments and will help to understand, at the molecular level, the strategies for fungal disease management. Expand
1 ACCESSING MICROBIAL LIFEWORLDS Weird Entanglements and Strange Symbionts
Beginning with an analysis of the discovery of endosymbiosis—the finding that the mitochondria of eukaryotic cells are derived from a once free-living bacterial ancestor—this paper is concerned withExpand
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The data suggest that the last eukaryotic common ancestor (LECA) already contained all three types of PufSF proteins and that ‘classical’ Pufs then underwent lineage-specific expansions. Expand
Prototypic SNARE proteins are encoded in the genomes of Heimdallarchaeota, potentially bridging the gap between the prokaryotes and eukaryotes
This work has identified SNARE-like factors in the genomes of uncultured organisms of Asgard archaea of the Heimdallarchaeota clade, which are thought to be the closest living relatives of eukaryotes, and identified several genes encoding for SNARE proteins in γ-proteobacteria of the order Legionellales, pathogens that live inside eukARYotic cells. Expand
The Autophagy Machinery in Human-Parasitic Protists; Diverse Functions for Universally Conserved Proteins
The current state of knowledge in parasitic protists is summarized, in the light of the latest important findings from more canonical model organisms, to help understand the evolutionary background of autophagy. Expand
Evolution and Natural History of Membrane Trafficking in Eukaryotes
Interesting variation exists that speaks to the evolutionary forces that have shaped the endomembrane system in eukaryotes and highlights ways in which membrane trafficking in protists differs from that in the authors' well-understood models of mammalian and yeast cells. Expand
Prototypic SNARE Proteins Are Encoded in the Genomes of Heimdallarchaeota, Potentially Bridging the Gap between the Prokaryotes and Eukaryotes
A defining feature of eukaryotic cells is the presence of numerous membrane-bound organelles that subdivide the intracellular space into distinct compartments. How the eukaryotic cell acquired itsExpand
The kinetochore and the origin of eukaryotic chromosome segregation
  • Mark C. Field
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2019
The origin of a key component, the KT, is revisited, using highly sensitive sequence and architectural search methods to provide a possible evolutionary history of eukaryote evolutionary history. Expand


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Multiple reconstructed cellular systems indicate a very sophisticated biology, which by implication arose following the initial eukaryogenesis event but prior to eUKaryotic radiation and provides a challenge in terms of explaining how these early eukARYotes arose and in understanding how they lived. Expand
An Alternative Root for the Eukaryote Tree of Life
A carefully vetted data set, consisting of 37 nuclear-encoded proteins of close bacterial ancestry (euBacs) and their closest bacterial relatives, augmented by deep sequencing of the Acrasis kona (Heterolobosea, Discoba), produces a highly robust, fully resolved global phylogeny of eukaryotes. Expand
Mitochondrial and Eukaryotic Origins: A Critical Review
Although all theories on eukaryotic origins lack evidence for one or more of the predicted evolutionary intermediates (in the form of modern descendants), symbiogenesis scenarios have an additional shortcoming: they do not account for the evolutionary time span required for creating thousands of genes that encode eUKaryotic subcellular structures. Expand
Eukaryotic origins: How and when was the mitochondrion acquired?
It is shown here that the associations between specific cell biological models of eukaryogenesis and evolutionary genomic data are not as strong as many suppose. Expand
On the age of eukaryotes: evaluating evidence from fossils and molecular clocks.
It is shown that for major eukaryote groups estimated dates of divergence, as well as their credible intervals, are heavily influenced by the relaxed molecular clock models and methods used, and by the nature and treatment of fossil calibrations. Expand
Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell
The results of this study demonstrate a major increase in the level of gene paralogy as a hallmark of the early evolution of eukaryotes. Expand
Archaea and the origin of eukaryotes
A brief history of the changing shape of the tree of life is outlined and how the recent discovery of a myriad of diverse archaeal lineages has changed the authors' understanding of the evolutionary relationships between the three domains of life and the origin of eukaryotes is examined. Expand
Late acquisition of mitochondria by a host with chimeric prokaryotic ancestry
It is argued that mitochondrial endosymbiosis was one of the ultimate steps in eukaryogenesis and that it provided the definitive selective advantage to mitochondria-bearing eUKaryotes over less complex forms. Expand
Open Questions on the Origin of Eukaryotes.
It is argued that, in addition to improved phylogenomic analyses with more comprehensive taxon sampling to pinpoint the closest prokaryotic relatives of eukaryotes, determining plausible mechanisms and selective forces at the origin of key eUKaryotic features, such as the nucleus or the bacterial-like Eukaryotic membrane system, is essential to constrain existing models. Expand
Energetics and genetics across the prokaryote-eukaryote divide
  • N. Lane
  • Medicine, Biology
  • Biology Direct
  • 2011
The combination of massive bioenergetic expansion, release from genome-size constraints, and high mutation rate explained the unique origin of eukaryotes, the absence of true evolutionary intermediates, and the evolution of sex in eukaries but not prokaryotes. Expand