Concepts of the last eukaryotic common ancestor

  title={Concepts of the last eukaryotic common ancestor},
  author={Maureen A. O’Malley and Michelle M. Leger and Jeremy G. Wideman and I{\~n}aki Ruiz-Trillo},
  journal={Nature Ecology \& Evolution},
Insight into the last eukaryotic common ancestor (LECA) is central to any phylogeny-based reconstruction of early eukaryotic evolution. [] Key Method Here the authors examine four potential forms of LECA: an abstract phylogenetic state, a single cell, a population, and a consortium of organisms.
Reconstructing the Last Common Ancestor: Epistemological and Empirical Challenges.
It is argued that LGT poses insurmountable challenges for detailed and rich in details reconstructions and proposed a middle-ground position with the reconstruction of a slim LCA based on traits under strong pressures of Negative Natural Selection, and for the need of consilience with evidence from organismal biology and geochemistry.
Reconciling Asgardarchaeota Phylogenetic Proximity to Eukaryotes and Planctomycetes Cellular Features in the Evolution of Life
  • D. Devos
  • Biology
    Molecular biology and evolution
  • 2021
The single-domain model is better suited to explain the origin and evolution of all three domains of life, blurring the distinctions between them and solves most of the ambiguities associated with the ones based on two ancestral domains.
Importance of Prokaryotes for the Origin of Eukaryotes and the Global Environment at 2.4-2.0 Ga
This work has shown that primitive genes for eukaryotic signature proteins, including actin and tubulin in the cytoskeleton and the ESCRT complex, which is involved in nuclear membrane formation, already existed in the genomes of archaeal species.
Archaeal origins of gamete fusion
A new hypothesis on the origins of eukaryotic sex where an archaeal fusexin was repurposed to enable gamete fusion is proposed, and it is demonstrated that ectopically expressed FusexinA can fuse mammalian cells and that this process involves the additional domain and a more broadly conserved fusion loop.
Fungal Mitogenomes: Relevant Features to Planning Plant Disease Management
The mechanisms that generate changes along mt-genomes are described, which play key roles at enlarging the ability of fungi to adapt to changing environments and will help to understand, at the molecular level, the strategies for fungal disease management.
1 ACCESSING MICROBIAL LIFEWORLDS Weird Entanglements and Strange Symbionts
It is argued that the weirdness of the microbial world is to be found in its recalcitrance and difficulty to be contained and that an alternative ontology—that of subtending relations—may more productively encompass human-microbe relations.
The evolution of the Puf superfamily of proteins across the tree of eukaryotes
The data suggest that the last eukaryotic common ancestor (LECA) already contained all three types of PufSF proteins and that ‘classical’ Pufs then underwent lineage-specific expansions.
Prototypic SNARE proteins are encoded in the genomes of Heimdallarchaeota, potentially bridging the gap between the prokaryotes and eukaryotes
This work has identified SNARE-like factors in the genomes of uncultured organisms of Asgard archaea of the Heimdallarchaeota clade, which are thought to be the closest living relatives of eukaryotes, and identified several genes encoding for SNARE proteins in γ-proteobacteria of the order Legionellales, pathogens that live inside eukARYotic cells.
The Autophagy Machinery in Human-Parasitic Protists; Diverse Functions for Universally Conserved Proteins
The current state of knowledge in parasitic protists is summarized, in the light of the latest important findings from more canonical model organisms, to help understand the evolutionary background of autophagy.


Molecular paleontology and complexity in the last eukaryotic common ancestor
Multiple reconstructed cellular systems indicate a very sophisticated biology, which by implication arose following the initial eukaryogenesis event but prior to eUKaryotic radiation and provides a challenge in terms of explaining how these early eukARYotes arose and in understanding how they lived.
Eukaryotic origins: How and when was the mitochondrion acquired?
It is shown here that the associations between specific cell biological models of eukaryogenesis and evolutionary genomic data are not as strong as many suppose.
On the age of eukaryotes: evaluating evidence from fossils and molecular clocks.
It is shown that for major eukaryote groups estimated dates of divergence, as well as their credible intervals, are heavily influenced by the relaxed molecular clock models and methods used, and by the nature and treatment of fossil calibrations.
Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell
The results of this study demonstrate a major increase in the level of gene paralogy as a hallmark of the early evolution of eukaryotes.
Archaea and the origin of eukaryotes
A brief history of the changing shape of the tree of life is outlined and how the recent discovery of a myriad of diverse archaeal lineages has changed the authors' understanding of the evolutionary relationships between the three domains of life and the origin of eukaryotes is examined.
Late acquisition of mitochondria by a host with chimeric prokaryotic ancestry
It is argued that mitochondrial endosymbiosis was one of the ultimate steps in eukaryogenesis and that it provided the definitive selective advantage to mitochondria-bearing eUKaryotes over less complex forms.
Energetics and genetics across the prokaryote-eukaryote divide
The combination of massive bioenergetic expansion, release from genome-size constraints, and high mutation rate explained the unique origin of eukaryotes, the absence of true evolutionary intermediates, and the evolution of sex in eukaries but not prokaryotes.