Concepts of interaction.

  title={Concepts of interaction.},
  author={Kenneth J. Rothman and Sander Greenland and Alexander M. Walker},
  journal={American journal of epidemiology},
  volume={112 4},
Readers of the American Journal of Epidemiology have seen a lively discourse on the topic of synergy, a major conceptual area in epidemiology for which there exists fundamental controversy as to definitions. In 1974, one of us (KJR) (1) proposed that synergy (or its negative counterpart, antagonism) between two or more causes of disease ought to be evaluated in reference to a specific yardstick. The reference point was one that equated independence of the causes with the situation in which the… Expand

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Interaction in epidemiologic studies.
Synergism and interaction: are they equivalent?
Additive, multiplicative, and other models for disease risks.
Synergy and antagonism in cause-effect relationships.
  • K. Rothman
  • Medicine
  • American journal of epidemiology
  • 1974