Concepts in the pathogenesis of rabies.

  title={Concepts in the pathogenesis of rabies.},
  author={Bernhard Dietzschold and Jianwei Li and Milosz Faber and Matthias J Schnell},
  journal={Future virology},
  volume={3 5},
Rabies is a zoonotic disease that remains an important public health problem worldwide and causes more than 70,000 human deaths each year. The causative agent of rabies is rabies virus (RV), a negative-stranded RNA virus of the rhabdovirus family. Neuroinvasiveness and neurotropism are the main features that define the pathogenesis of rabies. Although RV pathogenicity is a multigenic trait involving several elements of the RV genome, the RV glycoprotein plays a major role in RV pathogenesis by… CONTINUE READING