Concepts in sumoylation: a decade on

  title={Concepts in sumoylation: a decade on},
  author={Ruth Geiss-Friedlander and Frauke Melchior},
  journal={Nature Reviews Molecular Cell Biology},
A decade has passed since SUMO (small ubiquitin-related modifier) was discovered to be a reversible post-translational protein modifier. During this time many enzymes that participate in regulated SUMO-conjugation and -deconjugation pathways have been identified and characterized. In parallel, the search for SUMO substrates has produced a long list of targets, which appear to be involved in most cellular functions. Sumoylation is a highly dynamic process and its outcomes are extremely diverse… 
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