Concepts, labeling procedures, and design of cell proliferation studies relating to carcinogenesis.

@article{Goldsworthy1993ConceptsLP,
  title={Concepts, labeling procedures, and design of cell proliferation studies relating to carcinogenesis.},
  author={Thomas L. Goldsworthy and Byron E. Butterworth and Robert R Maronpot},
  journal={Environmental Health Perspectives},
  year={1993},
  volume={101},
  pages={59 - 65}
}
Chemicals may induce cell proliferation directly as mitogens or indirectly via cell death with subsequent proliferation to replace lost cells. Chemically induced proliferation has been demonstrated to play a role in the carcinogenic process. A wide range of procedures and techniques are currently being used to define the quantitative relationship between the extent and duration of chemically induced cell proliferation and carcinogenic potential in different species and target organs. However, a… CONTINUE READING

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