Conception and pharmacodynamic profile of drospirenone
@article{Elger2003ConceptionAP, title={Conception and pharmacodynamic profile of drospirenone}, author={Walter Dr Elger and Sybille Dr. Beier and Kunhard Pollow and Robert E. Garfield and S Q Shi and Alexander Hillisch}, journal={Steroids}, year={2003}, volume={68}, pages={891-905} }
112 Citations
Drospirenone and its antialdosterone
- Biology, Medicine
- 2007
The combined actions of drospirenone on sodium and water retention and cardiovascular parameters make it a more attractive therapeutic option as a component of hormone replacement therapy than other synthetic progestins.
Drospirenone and its antialdosterone properties
- Biology, MedicineClimacteric : the journal of the International Menopause Society
- 2007
The combined actions of drospirenone on sodium and water retention and cardiovascular parameters make it a more attractive therapeutic option as a component of hormone replacement therapy than other synthetic progestins.
Drospirenone, a New Progestogen, for Postmenopausal Women with Hypertension
- MedicineDrugs & aging
- 2007
Drospirenone is a unique progestogen that confers the additional benefit of BP reduction, an effect that could lead to potential benefit with respect to some cardiovascular risk concerns in women taking hormone therapy.
Pharmacology of different progestogens: the special case of drospirenone
- Biology, MedicineClimacteric : the journal of the International Menopause Society
- 2005
Drospirenone, which has pharmacodynamic properties very similar to those of progesterone, has been developed as a combined oral contraceptive and may counteract the negative effect of androgens on hair growth, lipid changes, insulin and, possibly, body composition in postmenopausal women.
Advances in hormone replacement therapy with drospirenone, a unique progestogen with aldosterone receptor antagonism.
- Biology, MedicineMaturitas
- 2006
Medroxyprogesterone Acetate But Not Drospirenone Ablates the Protective Function of 17β-Estradiol in Aldosterone Salt-Treated Rats
- Biology, MedicineHypertension
- 2006
The hypothesis of complex interactions among estrogen, progesterone, glucocorticoid, androgen, and mineralocortICoid receptor signaling in cardiovascular injury and inflammation is supported.
Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors.
- Biology, MedicineHuman reproduction
- 2007
The results help to interpret the anti-hypertensive effects of hormonal therapies containing Drospirenone and compare them with those of progesterone (P) and of medroxyprogesterone acetate (MPA).
Drospirenone with 17β-estradiol in the postmenopausal woman with hypertension
- Medicine, BiologyClimacteric : the journal of the International Menopause Society
- 2007
Findings suggest a potential additional benefit on the cardiovascular system for the drospirenone/17β-estradiol combination in the treatment of women with menopausal symptoms and elevated blood pressure.
Effects of synthetic gestagens on fish reproduction
- Environmental ScienceEnvironmental toxicology and chemistry
- 2009
The effects of two progestins currently marketed in contraceptive formulations, levonorgestrel (LNG) and drospirenone (DRSP), were investigated in adult fathead minnows following an Organization for Economic Cooperation and Development 21-d fish reproduction screening assay draft protocol with additional end points.
References
SHOWING 1-10 OF 71 REFERENCES
Drospirenone: a Novel Progestogen with Antimineralocorticoid and Antiandrogenic Activity
- Biology, MedicineAnnals of the New York Academy of Sciences
- 1995
Drospirenone exerts potent progestogenic and antigonadotropic activity which was studied in various animal species and efficiently promotes the maintenance of pregnancy in ovariectomized rats, inhibits ovulation in rats and mice and stimulates endometrial transformation in the rabbit.
Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity. Pharmacological characterization in animal models.
- Biology, MedicineContraception
- 1995
The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential.
- Biology, MedicineContraception
- 1996
Effects of a new oral contraceptive containing an antimineralocorticoid progestogen, drospirenone, on the renin-aldosterone system, body weight, blood pressure, glucose tolerance, and lipid metabolism.
- Medicine, BiologyThe Journal of clinical endocrinology and metabolism
- 1995
To the authors' knowledge, this is the first report on a combined OC that leads to a small decrease in body weight and blood pressure and may be especially beneficial for women susceptible for a gain in weight and a rise in blood pressure.
Effect of an oral contraceptive containing drospirenone on the renin-angiotensin-aldosterone system in healthy female volunteers
- Medicine, BiologyGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- 2000
Overall, the results indicate that 30 μg ethinylestradiol/3 mg drospirenone has a distinct antimineralocorticoid effect.
Dihydrospirorenone, a new progestogen with antimineralocorticoid activity: effects on ovulation, electrolyte excretion, and the renin-aldosterone system in normal women.
- Medicine, BiologyThe Journal of clinical endocrinology and metabolism
- 1991
It is concluded that DHSP may be a suitable partner of ethinyl estradiol as a constituent of an oral contraceptive, since its progestogenic and antialdosterone profile is similar to that of progesterone.
Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure
- Medicine, BiologySteroids
- 1996
Dihydrospirorenone (ZK30595): a novel synthetic progestagen--characterization of binding to different receptor proteins.
- Biology, ChemistryContraception
- 1992
Progestogens with antimineralocorticoid activity.
- Biology, MedicineArzneimittel-Forschung
- 1985
Gestodene may be regarded as the first progestogen of the nortestosterone series exhibiting a more natural, progesterone-like profile of activity and the antimineralocorticoid activity of the steroids tested could also be demonstrated after oral administration.