Conception and pharmacodynamic profile of drospirenone

@article{Elger2003ConceptionAP,
  title={Conception and pharmacodynamic profile of drospirenone},
  author={Walter Dr Elger and Sybille Dr. Beier and Kunhard Pollow and Robert E. Garfield and S Q Shi and Alexander Hillisch},
  journal={Steroids},
  year={2003},
  volume={68},
  pages={891-905}
}
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112 Citations
Highly Influential Citations
6
Background Citations
33
Methods Citations
1
Results Citations
1

112 Citations

Drospirenone and its antialdosterone

The combined actions of drospirenone on sodium and water retention and cardiovascular parameters make it a more attractive therapeutic option as a component of hormone replacement therapy than other synthetic progestins.

Drospirenone and its antialdosterone properties

The combined actions of drospirenone on sodium and water retention and cardiovascular parameters make it a more attractive therapeutic option as a component of hormone replacement therapy than other synthetic progestins.

Drospirenone, a New Progestogen, for Postmenopausal Women with Hypertension

Drospirenone is a unique progestogen that confers the additional benefit of BP reduction, an effect that could lead to potential benefit with respect to some cardiovascular risk concerns in women taking hormone therapy.

Pharmacology of different progestogens: the special case of drospirenone

  • R. Sitruk-Ware
  • Biology, Medicine
    Climacteric : the journal of the International Menopause Society
  • 2005
Drospirenone, which has pharmacodynamic properties very similar to those of progesterone, has been developed as a combined oral contraceptive and may counteract the negative effect of androgens on hair growth, lipid changes, insulin and, possibly, body composition in postmenopausal women.

Advances in hormone replacement therapy with drospirenone, a unique progestogen with aldosterone receptor antagonism.

Medroxyprogesterone Acetate But Not Drospirenone Ablates the Protective Function of 17β-Estradiol in Aldosterone Salt-Treated Rats

The hypothesis of complex interactions among estrogen, progesterone, glucocorticoid, androgen, and mineralocortICoid receptor signaling in cardiovascular injury and inflammation is supported.

The use of newer progestins for contraception.

Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors.

The results help to interpret the anti-hypertensive effects of hormonal therapies containing Drospirenone and compare them with those of progesterone (P) and of medroxyprogesterone acetate (MPA).

Drospirenone with 17β-estradiol in the postmenopausal woman with hypertension

  • W. White
  • Medicine, Biology
    Climacteric : the journal of the International Menopause Society
  • 2007
Findings suggest a potential additional benefit on the cardiovascular system for the drospirenone/17β-estradiol combination in the treatment of women with menopausal symptoms and elevated blood pressure.

Effects of synthetic gestagens on fish reproduction

The effects of two progestins currently marketed in contraceptive formulations, levonorgestrel (LNG) and drospirenone (DRSP), were investigated in adult fathead minnows following an Organization for Economic Cooperation and Development 21-d fish reproduction screening assay draft protocol with additional end points.
...

References

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Drospirenone: a Novel Progestogen with Antimineralocorticoid and Antiandrogenic Activity

Drospirenone exerts potent progestogenic and antigonadotropic activity which was studied in various animal species and efficiently promotes the maintenance of pregnancy in ovariectomized rats, inhibits ovulation in rats and mice and stimulates endometrial transformation in the rabbit.

Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity. Pharmacological characterization in animal models.

The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential.

Effects of a new oral contraceptive containing an antimineralocorticoid progestogen, drospirenone, on the renin-aldosterone system, body weight, blood pressure, glucose tolerance, and lipid metabolism.

To the authors' knowledge, this is the first report on a combined OC that leads to a small decrease in body weight and blood pressure and may be especially beneficial for women susceptible for a gain in weight and a rise in blood pressure.

Effect of an oral contraceptive containing drospirenone on the renin-angiotensin-aldosterone system in healthy female volunteers

Overall, the results indicate that 30 μg ethinylestradiol/3 mg drospirenone has a distinct antimineralocorticoid effect.

Dihydrospirorenone, a new progestogen with antimineralocorticoid activity: effects on ovulation, electrolyte excretion, and the renin-aldosterone system in normal women.

It is concluded that DHSP may be a suitable partner of ethinyl estradiol as a constituent of an oral contraceptive, since its progestogenic and antialdosterone profile is similar to that of progesterone.

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Gestodene may be regarded as the first progestogen of the nortestosterone series exhibiting a more natural, progesterone-like profile of activity and the antimineralocorticoid activity of the steroids tested could also be demonstrated after oral administration.
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