Concept of vulnerable/unstable plaque.

  title={Concept of vulnerable/unstable plaque.},
  author={Aloke Virmani Finn and Masataka Nakano and Jagat S. Narula and Frank D Kolodgie and Renu Virmani},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={30 7},
Today's concept of vulnerable plaque has evolved primarily from the early pioneering work uncovering the pivotal role of plaque rupture and coronary thrombosis as the major cause of acute myocardial infarction and sudden cardiac death. Since the first historical description of plaque rupture in 1844, several key studies by leading researchers and clinicians have lead to the current accepted views on lesion instability. Important to the complex paradigm of plaque destabilization and thrombosis… CONTINUE READING


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