Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics.

@article{Rushton2010ConceptOA,
  title={Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics.},
  author={Erik K Rushton and Jingkun Jiang and Stephen S. Leonard and Shirley Eberly and Vincent Castranova and Pratim Biswas and Alison Elder and Xianglu Han and Robert Gelein and Jacob N. Finkelstein and G{\"u}nther Oberd{\"o}rster},
  journal={Journal of toxicology and environmental health. Part A},
  year={2010},
  volume={73 5},
  pages={445-61}
}
Engineered nanoparticles (NP) are being developed and incorporated in a number of commercial products, raising the potential of human exposure during manufacture, use, and disposal. Although data concerning the potential toxicity of some NP have been reported, validated simple assays are lacking for predicting their in vivo toxicity. The aim of this study was to evaluate new response metrics based on chemical and biological activity of NP for screening assays that can be used to predict NP… CONTINUE READING
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