The new edition of the textbook e.g. describes thoroughly the serine protease
- L. Stryer, J. M. Berg, J. L. Tymoczko
A typical enzyme reaction runs through several steps. The structure of the enzymesubstrate intermediate in each step is reorganized to an optimal state to pass the next transition state. A very limited number of basic chemical catalytic principles are used in each transition state, and this is accomplished by a limited number of functional groups like amino acid side chains. Various methods of kinetic and structural studies are used to understand the function of the intermediates and transition states.