Concentric demyelination by self-organization: a new hypothesis for Baló's sclerosis

@article{Khonsari2007ConcentricDB,
  title={Concentric demyelination by self-organization: a new hypothesis for Bal{\'o}'s sclerosis},
  author={Roman Hossein Khonsari and Vincent Calvez},
  journal={Nature Clinical Practice Neurology},
  year={2007},
  volume={3},
  pages={E1-E1}
}
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Balo’s Concentric Sclerosis Mimicking Tumor on Magnetic Resonance Imaging in a Young Patient
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A 26-y-old male developed headache, weakness, and numbness of limbs and Magnetic resonance imaging showed concentric lamellar like demyelinating lesions at the subcortical regions, which were consistent with the MRI findings.
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Based on a clear-cut Balò's lesion analysis, early changes in DWI and ADC values within the different layers are described, favoring the concept of a centrifugal growth.
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Current data and treatment strategy in GBM are presented focusing on basic science data and key clinical aspects like surgery, including personal experience; adjuvant modalities: radiotherapy, chemotherapy, but also for experimental approaches.
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Concentric high signal intensity zones on T2-weighted magnetic resonance images of brain strongly suggest Balo's concentric sclerosis, a rare but recognized variant of multiple sclerosis, allowing earlier diagnosis and therapy of the disease.

References

SHOWING 1-5 OF 5 REFERENCES
Technology Insight: can neuroimaging provide insights into the role of ischemia in Baló's concentric sclerosis?
TLDR
Evidence from longitudinal neuroimaging studies that supports the role of ischemic preconditioning in Baló's concentric sclerosis is discussed.
The Origins of Concentric Demyelination: Self-Organization in the Human Brain
TLDR
A robust mathematical model is proposed for Baló's sclerosis, sharing common molecular and cellular mechanisms with multiple sclerosis, and homogeneous and concentric demyelinations may be two different macroscopic outcomes of a single fundamental immune disorder.
Tissue preconditioning may explain concentric lesions in Baló's type of multiple sclerosis.
TLDR
Investigation of immunopathology in autopsy tissue of 14 patients with acute multiple sclerosis or fulminant exacerbations of chronic multiple sclerosis with Baló-type lesions in the CNS found that all active concentric lesions followed a pattern of demyelination that bears resemblances to hypoxia-like tissue injury.
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