Concentric demyelination by self-organization: a new hypothesis for Baló's sclerosis

@article{Khonsari2007ConcentricDB,
  title={Concentric demyelination by self-organization: a new hypothesis for Bal{\'o}'s sclerosis},
  author={Roman Hossein Khonsari and Vincent Calvez},
  journal={Nature Clinical Practice Neurology},
  year={2007},
  volume={3},
  pages={E1-E1}
}
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Evidence from longitudinal neuroimaging studies that supports the role of ischemic preconditioning in Baló's concentric sclerosis is discussed.
The Origins of Concentric Demyelination: Self-Organization in the Human Brain
TLDR
A robust mathematical model is proposed for Baló's sclerosis, sharing common molecular and cellular mechanisms with multiple sclerosis, and homogeneous and concentric demyelinations may be two different macroscopic outcomes of a single fundamental immune disorder.
Tissue preconditioning may explain concentric lesions in Baló's type of multiple sclerosis.
TLDR
Investigation of immunopathology in autopsy tissue of 14 patients with acute multiple sclerosis or fulminant exacerbations of chronic multiple sclerosis with Baló-type lesions in the CNS found that all active concentric lesions followed a pattern of demyelination that bears resemblances to hypoxia-like tissue injury.
Über die konzentrische Sklerose und die physikalischchemischen Faktoren bei der Ausbreitung von Entmarkungsprozessen
Zusammenfassung1.Unter der Bezeichnung „konzentrische Sklerose“ werden 2 eigene Beobachtungen und 4 Fälle aus der Literatur, die wir meist mehr oder weniger genau nachuntersuchen konnten,
Recent Theoretical Developments on the Formation of Liesegang Patterns
When an electrolyte A diffuses into a gel containing another electrolyte B, the eventual formation of a rhythmic pattern of precipitate by the moving chemical reaction front is known as the Liesegang