Concentrations ofd-lactate and its related metabolic intermediates in liver, blood, and muscle of diabetic and starved rats

@article{Kondoh1992ConcentrationsOA,
  title={Concentrations ofd-lactate and its related metabolic intermediates in liver, blood, and muscle of diabetic and starved rats},
  author={Y. Kondoh and M. Kawase and Y. Kawakami and S. Ohmori},
  journal={Research in Experimental Medicine},
  year={1992},
  volume={192},
  pages={407-414}
}
SummaryThis is a report investigating the methylglyoxal (MG) bypass in animals, by whichd-lactate is produced from triosephosphate via MG. Rats were made diabetic using streptozotocin or starved for 72 h.d-Lactate and various metabolites related to it, such asl-lactate, pyruvate, methylglyoxal, glucose, and inorganic phosphate, were measured in the blood plasma, liver, and skeletal muscle of the rats. Diabetic and starved rats had significantly higher levels ofd-lactate in plasma, liver, and… Expand
Contents of D-lactate and its related metabolites as well as enzyme activities in the liver, muscle and blood plasma of aging rats
TLDR
It is observed that rats above 27 months old were decrepit as judged by external appearance movement and other physiological data of them and age-related changes in the levels of D-lactate and its related compounds in rat tissues are reported. Expand
D-Lactate altered mitochondrial energy production in rat brain and heart but not liver
TLDR
DLA was a poor respiratory substrate in brain and heart mitochondria and inhibited LLA and pyruvate usage in these tissues, and further studies are warranted to evaluate whether these findings support the possible neurological and cardiac toxicity caused by high DLA levels. Expand
Increased serum D-lactate associated with diabetic ketoacidosis.
TLDR
The data suggest that hepatic ketone metabolism, rather than hyperglycemia, may be a major source of serum D-lactate in diabetics, and in vitro erythrocyte D- lactate formation did not increase in the presence of hyper glycemia. Expand
Carbon sources for D-lactate formation in rat liver.
TLDR
Glycerol was the best substrate for D-lactate formation via methylglyoxal in rat liver and the glycerol kinase activities in livers increased in the diabetic and starved states, which can explain why the plasma concentration of D- lactate increases several-fold after running. Expand
Changes in concentrations of methylglyoxal,d-lactate and glyoxalase activities in liver and plasma of rats fed a 3′-methyl-4-dimethylaminoazobenzene-rich diet
  • M. Kawase, M. Tada, S. Akagi, S. Ohmori
  • Chemistry, Medicine
  • Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
  • 1996
TLDR
Donryu male albino rats were fed a diet containing 0.064% 3′-methyl-4-dimethylaminoazobenzene (MDAB) for 21 weeks and changes in the concentrations of methylglyoxal,d-lactate and glutathione as well as activities of glyoxalase I and II in liver and plasma were examined. Expand
D-lactate in human and ruminant metabolism.
TLDR
Advances in the understanding of D-lactate metabolism, D- lactic acidosis in ruminants and humans, and subclinical elevation of d- lactate are described. Expand
D-Lactate transport and metabolism in rat liver mitochondria.
TLDR
The D-lactate translocators, in the light of their different inhibition profiles separate from the monocarboxylate carrier, were found to differ from each other in the V(max) values and in the inhibition and pH profiles and were shown to regulate mitochondrial D- lactate metabolism in vitro. Expand
Formate excretion in urine of rats fed dimethylaminoazobenzene-rich diets: the possibility of formate formation from D-lactate.
TLDR
The most striking results were the elevated formate levels in the urine of rats fed 3'- and 4'-MDAB in a precancerous state, which can explain the elevated levels of methylglyoxal and D-lactate in the liver. Expand
Aminoguanidine partially prevents the reduction in liver pyruvate kinase activity in diabetic rats
Background : Low molecular weight aldehydes and carbonyl compounds which are derived from glucose metabolism are prevalent in diabetic plasma. These compounds react to amino groups of Lys and Arg andExpand
D-lactate metabolism in starved Octopus ocellatus.
TLDR
The experimental results presented in this report and up to the present indicate that D-lactate is actively used for energy production in the tentacle and mantle of the starved animals. Expand
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