Concentrations of MDPV in rat striatum correlate with the psychostimulant effect.

  title={Concentrations of MDPV in rat striatum correlate with the psychostimulant effect.},
  author={Judith Novellas and Ra{\'u}l L{\'o}pez-Arnau and Marcel li Carb{\'o} and David Pubill and Jorge Camarasa and E Escubedo},
  journal={Journal of psychopharmacology},
  volume={29 11},
3,4-methylenedioxypyrovalerone or MDPV is a synthetic cathinone with psychostimulant properties more potent than cocaine. We quantified this drug in the striatum after subcutaneous administration to rats. MDPV reached the brain around 5 min after its administration and peaked at 20-25 min later. The elimination half-life in the striatum (61 min) correlates with the decrease in the psychostimulant effect after 60 min. Around 11% of the administered dose reached the striatum and, considering a… CONTINUE READING
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