Persian Gulf supports diverse ecosystems and biota in need of remediation and protection and metal data from this region is needed. The levels of heavy metals (Fe, Hg, Ni and Pb) in tissues (hepatopancreas, muscle and exoskeleton) of blue swimming crab, Portunus pelagicus and sediments in the Persian Gulf coasts, south Iran were investigated. Heavy metals analysis was performed by Atomic Absorption Spectrophotometer. The concentration of heavy metals in sediments at all sampling stations occurs in descending order of Fe > Ni > Hg > Pb during both seasons. The distribution pattern of heavy metals in the tissues of crab and sediments was as follows: sediment > hepatopancreasn > muscle > exoskeleton. Maximum concentration of the total heavy metals in sediments and all tissues of P. pelagicus observes in Bahrekan station (P<0.05) during different seasons. There was no significant difference (P<0.05) between the level of heavy metals in the tissues of the crab P. pelagicus. In present study recorded that there was negligible differences in heavy metals levels between different seasons. Differences in heavy metals concentrations among the species is likely to have resulted from metal bioavailability, hydrodynamics of the environment, changes in tissue composition, stations of collection and sources of pollution within Persian Gulf.