Concentration rather than dose defines the local brain toxicity of agents that are effectively distributed by convection-enhanced delivery.

Abstract

BACKGROUND Convection-enhanced delivery (CED) has been developed as a potentially effective drug-delivery strategy into the central nervous system. In contrast to systemic intravenous administration, local delivery achieves high concentration and prolonged retention in the local tissue, with increased chance of local toxicity, especially with toxic agents… (More)
DOI: 10.1016/j.jneumeth.2013.11.004

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