Concentration of amoxycillin and clavulanate in lung compartments in adults without pulmonary infection.

@article{Cook1994ConcentrationOA,
  title={Concentration of amoxycillin and clavulanate in lung compartments in adults without pulmonary infection.},
  author={Philip J. Cook and Jennifer M. Andrews and Johanna Woodcock and Richard Wise and David Honeybourne},
  journal={Thorax},
  year={1994},
  volume={49 11},
  pages={1134-8}
}
BACKGROUND The efficacy of an antibiotic is usually predicted from serum levels and MIC90 values for likely pathogens, but in the lung tissue concentrations may be more informative. This study compares concentrations of amoxycillin and clavulanate in serum, epithelial lining fluid (ELF), alveolar macrophages, and bronchial mucosa in 15 adults. METHODS Amoxycillin 500 mg and clavulanic acid 250 mg were given 1-2 hours before diagnostic bronchoscopy for haemoptysis or radiological abnormality… CONTINUE READING

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Bactericidal effects of ticarcillin - clavulanic acid against Legionella pneumophila pneumonia in immunocompromised patients

Y Zhang, VA Steingrube, RJ Wallace
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