Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export

Abstract

Mechanisms for exporting variably sized cargo from the endoplasmic reticulum (ER) using the same machinery remain poorly understood. COPII-coated vesicles, which transport secretory proteins from the ER to the Golgi apparatus, are typically 60-90 nm in diameter. However, collagen, which forms a trimeric structure that is too large to be accommodated by… (More)
DOI: 10.1083/jcb.201312062

Topics

  • Presentations referencing similar topics