Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation

@article{Anderson2000ConcentrationOM,
  title={Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation},
  author={Howard A. Anderson and Elizabeth M. Hiltbold and Paul A. Roche},
  journal={Nature Immunology},
  year={2000},
  volume={1},
  pages={156-162}
}
The plasma membranes of eukaryotic cells are not uniform and possess distinct cholesterol– and sphingolipid–rich raft microdomains that are enriched in proteins known to be essential for cellular function. Lipid raft microdomains are important for T cell receptor (TCR)–mediated activation of T cells. However, the importance of lipid rafts on antigen presenting cells (APCs) and their role in major histocompatibility (MHC) class II–restricted antigen presentation has not been examined. MHC class… CONTINUE READING

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