Concentration-effect relationships for the drug of abuse gamma-hydroxybutyric acid.

@article{Felmlee2010ConcentrationeffectRF,
  title={Concentration-effect relationships for the drug of abuse gamma-hydroxybutyric acid.},
  author={Melanie A. Felmlee and Samuel A. Roiko and Bridget L. Morse and Marilyn E Morris},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={333 3},
  pages={764-71}
}
gamma-Hydroxybutyric acid (GHB) is an endogenous neurotransmitter that is abused because of its sedative/hypnotic and euphoric effects. The objectives of this study were to evaluate the concentration-effect relationships of GHB in plasma, cerebrospinal fluid (CSF), brain (whole and discrete brain regions), and brain frontal cortex extracellular fluid. This information is crucial for future studies to evaluate effects of therapeutic interventions on the toxicodynamics of GHB. GHB (200-1000 mg/kg… CONTINUE READING

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