Concentration-effect relationship of levodopa in patients with Parkinson's disease after oral administration of an immediate release and a controlled release formulation.

@article{Harder1995ConcentrationeffectRO,
  title={Concentration-effect relationship of levodopa in patients with Parkinson's disease after oral administration of an immediate release and a controlled release formulation.},
  author={S. Harder and H. Baas and N Bergemann and Lothar Demisch and Stephan Rietbrock},
  journal={British journal of clinical pharmacology},
  year={1995},
  volume={39 1},
  pages={39-44}
}
1. The relationship between plasma concentration of levodopa and motor-response was investigated in 12 patients with Parkinson's disease who showed marked response fluctuations, after a single oral dose of an immediate release (IR) formulation (100 mg levodopa/25 mg genserazide) and a controlled release (CR) formulation (300 mg levodopa/75 mg benserazide), using a double-blind, randomized, cross-over design. 2. The sum score of the Columbia University Rating Scale (CURS sigma) was used for… CONTINUE READING