Concentration-effect relationship of delta-9-tetrahydrocannabiol and prediction of psychotropic effects after smoking marijuana.

@article{Harder1997ConcentrationeffectRO,
  title={Concentration-effect relationship of delta-9-tetrahydrocannabiol and prediction of psychotropic effects after smoking marijuana.},
  author={S. Harder and Stephan Rietbrock},
  journal={International journal of clinical pharmacology and therapeutics},
  year={1997},
  volume={35 4},
  pages={155-9}
}
On the basis of a publication by Cochetto et al. [1981] we performed simulations of the effect-time course (high-rating) after smoking marijuana. The intention was to characterize the concentration-effect relationship of THC and to provide information on how long psychotropic effects (and therefore impairment of cognitive or motoric functions) last after intake of a cannabinoid product. The parameter estimates (+/-SD) of the pharmacokinetic disposition and the pharmacodynamic model (sigmoidal… CONTINUE READING

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