Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues.

@article{Ndelec2012ConcentrationdependentRF,
  title={Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues.},
  author={St{\'e}phane N{\'e}delec and Mirza Peljto and Peng Shi and Mackenzie Weygandt Mathis and Lance C. Kam and Hynek Wichterle},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 4},
  pages={1496-506}
}
Formation of functional motor circuits relies on the ability of distinct spinal motor neuron subtypes to project their axons with high precision to appropriate muscle targets. While guidance cues contributing to motor axon pathfinding have been identified, the intracellular pathways underlying subtype-specific responses to these cues remain poorly understood. In particular, it remains controversial whether responses to axon guidance cues depend on axonal protein synthesis. Using a growth cone… CONTINUE READING
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