Concentration-dependent realignment of the antimicrobial peptide PGLa in lipid membranes observed by solid-state 19F-NMR.

@article{Glaser2005ConcentrationdependentRO,
  title={Concentration-dependent realignment of the antimicrobial peptide PGLa in lipid membranes observed by solid-state 19F-NMR.},
  author={Ralf W. Glaser and Carsten Sachse and Ulrich H. N. D{\"u}rr and Parvesh Wadhwani and Sergii Afonin and Erik Strandberg and Anne S Ulrich},
  journal={Biophysical journal},
  year={2005},
  volume={88 5},
  pages={3392-7}
}
The membrane-disruptive antimicrobial peptide PGLa is found to change its orientation in a dimyristoyl-phosphatidylcholine bilayer when its concentration is increased to biologically active levels. The alignment of the alpha-helix was determined by highly sensitive solid-state NMR measurements of (19)F dipolar couplings on CF(3)-labeled side chains, and supported by a nonperturbing (15)N label. At a low peptide/lipid ratio of 1:200 the amphiphilic peptide resides on the membrane surface in the… CONTINUE READING

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