Concentration-dependent isoflurane effects on depolarization-evoked glutamate and GABA outflows from mouse brain slices.

@article{Liachenko1999ConcentrationdependentIE,
  title={Concentration-dependent isoflurane effects on depolarization-evoked glutamate and GABA outflows from mouse brain slices.},
  author={Serguei Liachenko and Pei Zong Tang and George T. Somogyi and Yan Xu},
  journal={British journal of pharmacology},
  year={1999},
  volume={127 1},
  pages={131-8}
}
The synaptic concentrations of glutamate and gamma-aminobutyric acid (GABA) are modulated by their release and re-uptake. The effects of general anaesthetics on these two processes remain unclear. This study evaluates the effects of isoflurane, a clinically important anaesthetic, on glutamate and GABA release and re-uptake in superfused mouse cerebrocortical slices. Experiments consisted of two 1.5-min exposures to 40 mM KCl in 30 min intervals. During the second exposure, different… CONTINUE READING