Concentration-dependent inversion of antioxidant and prooxidant effects of β-carotene in tissuesin vivo

@article{Lankin2006ConcentrationdependentIO,
  title={Concentration-dependent inversion of antioxidant and prooxidant effects of $\beta$-carotene in tissuesin vivo},
  author={Vadim Z. Lankin and Alla K. Tikhaze and Galina G. Konovalova and A. I. Kozachenko},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2006},
  volume={128},
  pages={930-932}
}
Low doses (below 20 mg/kg) of oral β-carotene inhibit, while high doses (above 100 mg/kg) activate ascorbate-dependent LPO in rat liver and myocardial cells. Administration of β-carotene in a dose of 20 mg/kg decreased by 34% infarction zone in coronary occlusion, while the dose of 100 mg/kg was ineffective. Anin vivo concentration-dependent inversion of β-carotene from antioxidant to prooxidant in tissues is hypothesized. Pharmacological efficacy of β-carotene is determined by its antioxidant… 
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