Concentration-dependent interactions of the organophosphates chlorpyrifos oxon and methyl paraoxon with human recombinant acetylcholinesterase.

@article{Kaushik2007ConcentrationdependentIO,
  title={Concentration-dependent interactions of the organophosphates chlorpyrifos oxon and methyl paraoxon with human recombinant acetylcholinesterase.},
  author={Rekha Kaushik and Clint A Rosenfeld and Lester G. Sultatos},
  journal={Toxicology and applied pharmacology},
  year={2007},
  volume={221 2},
  pages={243-50}
}
For many decades it has been thought that oxygen analogs (oxons) of organophosphorus insecticides phosphorylate the catalytic site of acetylcholinesterase by a mechanism that follows simple Michaelis-Menten kinetics. More recently, the interactions of at least some oxons have been shown to be far more complex and likely involve binding of oxons to a second site on acetylcholinesterase that modulates the inhibitory capacity of other oxon molecules at the catalytic site. The current study has… CONTINUE READING