Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells

@article{Znkler1988ConcentrationdependentEO,
  title={Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells},
  author={Bernd Joachim Z{\"u}nkler and Sigurd Lenzen and K. Manner and Uwe Panten and Gerhard Trube},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1988},
  volume={337},
  pages={225-230}
}
The influence of the hypoglycemic drugs tolbutamide, meglitinide, glipizide and glibenclamide on ATP-dependent K+ currents of mouse pancreatic B-cells was studied using the whole-cell configuration of the patch-clamp technique. In the absence of albumin, tolbutamide blocked the currents half maximally at 4.1 μmol/l. In the presence of 2 mg/ml albumin half maximal inhibition of the currents was observed at 2.1 μmol/l meglitinide, 6.4 nmol/l glipizide and 4.0 nmol/1 glibenclamide. The… CONTINUE READING

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Opposite actions of two structurally similar sulfonamides on an ATP sensitive K + channel in adult pancreatic B-cells and RINm5F insulinoma cells

  • K Gillis, W Gee, L Falke, S Misler
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