Concentration-dependent effects of cocaine on monoamine-induced constriction of cannulated, pressurized cerebral arteries from fetal sheep.

@article{Schreiber1995ConcentrationdependentEO,
  title={Concentration-dependent effects of cocaine on monoamine-induced constriction of cannulated, pressurized cerebral arteries from fetal sheep.},
  author={Michael D. Schreiber and Jane Madden and Robert F. Covert and Marc Hershenson and Lorna J. Torgerson},
  journal={Reproduction, fertility, and development},
  year={1995},
  volume={7 5},
  pages={1389-94}
}
Drugs, such as cocaine, which may alter monoamine neurotransmitter responsiveness, could adversely affect the regulation of cerebral vasculature. Cocaine exhibits at least two mechanisms that may alter vascular responsiveness: synaptic uptake inhibition, which may augment response to stimulation, and Na+ channel inhibition, which may attenuate response. To… CONTINUE READING