Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins

@article{Chen2012ConcentrationdependentCO,
  title={Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins},
  author={Mo Chen and C. J. Carpentier David and James L Manley},
  journal={Nature Structural &Molecular Biology},
  year={2012},
  volume={19},
  pages={346-354}
}
Expression of the mammalian pyruvate kinase M (PKM) gene provides an important example of mutually exclusive splicing. We showed previously that the hnRNP proteins A1, A2 and PTB have a crucial role in this process. Here we provide evidence that concentration-dependent interactions involving a network of these proteins are sufficient to determine the outcome of PKM splicing. At high concentrations, such as those found in most cancer cells, hnRNPA1 binding to two sites in the upstream regulated… CONTINUE READING
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