Concentration and Length Dependence of DNA Looping in Transcriptional Regulation

@article{Han2009ConcentrationAL,
  title={Concentration and Length Dependence of DNA Looping in Transcriptional Regulation},
  author={Lin Han and Hernan G. Garcia and Seth Blumberg and Kevin B. Towles and John F. Beausang and Philip C. Nelson and Rob Phillips},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={115 - 30}
}
In many cases, transcriptional regulation involves the binding of transcription factors at sites on the DNA that are not immediately adjacent to the promoter of interest. This action at a distance is often mediated by the formation of DNA loops: Binding at two or more sites on the DNA results in the formation of a loop, which can bring the transcription factor into the immediate neighborhood of the relevant promoter. These processes are important in settings ranging from the historic bacterial… CONTINUE READING
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