Concentration-EEG effect relationship of propofol in rats.

  title={Concentration-EEG effect relationship of propofol in rats.},
  author={Suvendra N. Dutta and Yukihiro Matsumoto and N U Gothgen and William F. Ebling},
  journal={Journal of pharmaceutical sciences},
  volume={86 1},
Propofol is a unique highly lipid-soluble anesthetic that is formulated in a fat emulsion (Diprivan) for intravenous (i.v.) use. It has the desirable properties of rapid onset and offset of effect following rapid i.v. administration and minimal accumulation on long-term administration. Based on physicochemical properties and preliminary brain solubility data, propofol should have an extended effect-site turnover and a resulting prolonged effect. However, a preliminary study in humans has… CONTINUE READING

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