Concentration-Dependent Effect of Naringin on Intestinal Absorption of β1-Adrenoceptor Antagonist Talinolol Mediated by P-Glycoprotein and Organic Anion Transporting Polypeptide (Oatp)

@article{Shirasaka2008ConcentrationDependentEO,
  title={Concentration-Dependent Effect of Naringin on Intestinal Absorption of β1-Adrenoceptor Antagonist Talinolol Mediated by P-Glycoprotein and Organic Anion Transporting Polypeptide (Oatp)},
  author={Yoshiyuki Shirasaka and Yan Li and Yuta Shibue and Erika Kuraoka and Hildegard Spahn-Langguth and Yukio Kato and Peter Langguth and Ikumi Tamai},
  journal={Pharmaceutical Research},
  year={2008},
  volume={26},
  pages={560-567}
}
The purpose of this study is to clarify the impact of P-gp and Oatp on intestinal absorption of the β1-adrenoceptor antagonist talinolol. P-gp-mediated transport was measured in LLC-PK1/MDR1 cells. Oatp-mediated uptake was evaluated with Xenopus oocytes expressing Oatp1a5. Rat intestinal permeability was measured by the in situ closed loop method. In vivo absorption was pharmacokinetically assessed by measuring plasma concentration after oral administration in rats. In LLC-PK1/MDR1 cells, the… CONTINUE READING