Concentration Addition, Independent Action and Generalized Concentration Addition Models for Mixture Effect Prediction of Sex Hormone Synthesis In Vitro

@inproceedings{Hadrup2013ConcentrationAI,
  title={Concentration Addition, Independent Action and Generalized Concentration Addition Models for Mixture Effect Prediction of Sex Hormone Synthesis In Vitro},
  author={Niels Hadrup and Camilla Taxvig and Mikael Pedersen and Christine Nellemann and Ulla Hass and Anne Marie Vinggaard},
  booktitle={PloS one},
  year={2013}
}
Humans are concomitantly exposed to numerous chemicals. An infinite number of combinations and doses thereof can be imagined. For toxicological risk assessment the mathematical prediction of mixture effects, using knowledge on single chemicals, is therefore desirable. We investigated pros and cons of the concentration addition (CA), independent action (IA) and generalized concentration addition (GCA) models. First we measured effects of single chemicals and mixtures thereof on steroid synthesis… CONTINUE READING

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