Concanavalin A-inducible, interleukin-2-producing T cell hybridoma

  title={Concanavalin A-inducible, interleukin-2-producing T cell hybridoma},
  author={Lee W. Harwell and Barry J Skidmore and Philippa Marrack and J W Kappler},
  journal={The Journal of Experimental Medicine},
  pages={893 - 904}
The fusion of an AKR T cell tumor line to normal B6D2F1, T cells resulted in the production of a cloned T cell hybridoma (FS6-14.13) inducible with the mitogen concanavalin A (Con A). The supernate from Con A-stimulated hybridoma cells was active both in the stimulation of an anti-sheep red blood cell response by partially T cell-depleted B cells and in the stimulation of the growth of antigen-specific T cell blasts. The active principle in both assays had a molecular weight of approximately 30… CONTINUE READING
Highly Cited
This paper has 1,073 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 30 extracted citations

1,074 Citations

Citations per Year
Semantic Scholar estimates that this publication has 1,074 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 27 references

Biochemical characterization of lymphocyte regulatory molecules. II. Purification of a class of rat and human lymphokines

  • S. Giilis, K. Smith, J. Watson
  • J. Immunol
  • 1980

Helper T cell interactions with B cells and macrophages

  • P. Marrack, L. Harwell, J. Kappler, D. Kawahara, D. Keller, J. Swierkosz
  • editors. Elsevier NorthHolland,
  • 1979

A new microcytotoxicity method for determining lymphoid chimerism by examination of peripheral blood lymphoeytes of murine bone marrow chimeras.J

  • B. Skidmore, L. Miller
  • Imrnunol. Methods
  • 1978

Similar Papers

Loading similar papers…