Concanavalin A—induced T‐cell—mediated hepatic injury in mice: The role of tumor necrosis factor

@article{Gantner1995ConcanavalinAT,
  title={Concanavalin A—induced T‐cell—mediated hepatic injury in mice: The role of tumor necrosis factor},
  author={F. Gantner and M. Leist and A. Lohse and P. Germann and Gisa Tiegs},
  journal={Hepatology},
  year={1995},
  volume={21}
}
Concanavalin A activates T lymphocytes in vitro and causes T‐cell‐dependent hepatic injury in mice. T lymphocytes were previously identified as effector cells of concanavalin A‐induced liver injury. Here we report that hepatic injury is characterized by apoptotic cell death. On concanavalin A challenge, the cytokines tumor necrosis factor‐α (TNF α), interleukin‐2, granulocyte macrophage‐colony stimulating factor, and interferon‐γ were detectable in the circulation of the mice. Pretreatment of… Expand
Fumigaclavine C improves concanavalin A‐induced liver injury in mice mainly via inhibiting TNF‐α production and lymphocyte adhesion to extracellular matrices
Bimodal role of endogenous interleukin‐6 in concanavalin A‐induced hepatitis in mice
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