ConSurf: Identification of Functional Regions in Proteins by Surface-Mapping of Phylogenetic Information

@article{Glaser2003ConSurfIO,
  title={ConSurf: Identification of Functional Regions in Proteins by Surface-Mapping of Phylogenetic Information},
  author={Fabian Glaser and Tal Pupko and Inbal Paz and Rachel E. Bell and Dalit Bechor-Shental and Eric Martz and Nir Ben-Tal},
  journal={Bioinformatics},
  year={2003},
  volume={19 1},
  pages={163-4}
}
UNLABELLED We recently developed algorithmic tools for the identification of functionally important regions in proteins of known three dimensional structure by estimating the degree of conservation of the amino-acid sites among their close sequence homologues. Projecting the conservation grades onto the molecular surface of these proteins reveals patches of highly conserved (or occasionally highly variable) residues that are often of important biological function. We present a new web server… CONTINUE READING
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