ConFunc - functional annotation in the twilight zone

  title={ConFunc - functional annotation in the twilight zone},
  author={Mark N. Wass and Michael J. E. Sternberg},
  volume={24 6},
MOTIVATION The success of genome sequencing has resulted in many protein sequences without functional annotation. We present ConFunc, an automated Gene Ontology (GO)-based protein function prediction approach, which uses conserved residues to generate sequence profiles to infer function. ConFunc split sets of sequences identified by PSI-BLAST into sub-alignments according to their GO annotations. Conserved residues are identified for each GO term sub-alignment for which a position specific… CONTINUE READING


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