Comrad: detection of expressed rearrangements by integrated analysis of RNA-Seq and low coverage genome sequence data

@article{McPherson2011ComradDO,
  title={Comrad: detection of expressed rearrangements by integrated analysis of RNA-Seq and low coverage genome sequence data},
  author={Andrew W McPherson and Chunxiao Wu and Iman Hajirasouliha and Fereydoun Hormozdiari and Faraz Hach and Anna Lapuk and Stanislav Volik and Sohrab P. Shah and Colin Collins and S{\"u}leyman Cenk Sahinalp},
  journal={Bioinformatics},
  year={2011},
  volume={27 11},
  pages={1481-8}
}
MOTIVATION Comrad is a novel algorithmic framework for the integrated analysis of RNA-Seq and whole genome shotgun sequencing (WGSS) data for the purposes of discovering genomic rearrangements and aberrant transcripts. The Comrad framework leverages the advantages of both RNA-Seq and WGSS data, providing accurate classification of rearrangements as expressed or not expressed and accurate classification of the genomic or non-genomic origin of aberrant transcripts. A major benefit of Comrad is… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

BreakTrans: uncovering the genomic architecture of gene fusions

Genome Biology • 2013
View 4 Excerpts
Highly Influenced

Characterization of drug-induced splicing complexity in prostate cancer cell line using long read technology.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing • 2018
View 1 Excerpt

Cancer Gene Profiling

Methods in Molecular Biology • 2016

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Detection and characterization of novel sequence insertions using paired-end next-generation sequencing

I Hajirasouliha
Bioinformatics • 2010

Integrative analysis of the melanoma transcriptome

Berger, M.F
Genome Res., • 2010

Similar Papers

Loading similar papers…