Computing the origin and evolution of the ribosome from its structure — Uncovering processes of macromolecular accretion benefiting synthetic biology

@inproceedings{CaetanoAnolls2015ComputingTO,
  title={Computing the origin and evolution of the ribosome from its structure — Uncovering processes of macromolecular accretion benefiting synthetic biology},
  author={Gustavo Caetano-Anoll{\'e}s and Derek Caetano-Anoll{\'e}s},
  booktitle={Computational and structural biotechnology journal},
  year={2015}
}
Accretion occurs pervasively in nature at widely different timeframes. The process also manifests in the evolution of macromolecules. Here we review recent computational and structural biology studies of evolutionary accretion that make use of the ideographic (historical, retrodictive) and nomothetic (universal, predictive) scientific frameworks. Computational studies uncover explicit timelines of accretion of structural parts in molecular repertoires and molecules. Phylogenetic trees of… CONTINUE READING
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