Computing Transient Gating Charge Movement of Voltage-Dependent Ion Channels

  title={Computing Transient Gating Charge Movement of Voltage-Dependent Ion Channels},
  author={Anthony Varghese and Linda M. Boland},
  journal={Journal of Computational Neuroscience},
The opening of voltage-gated sodium, potassium, and calcium ion channels has a steep relationship with voltage. In response to changes in the transmembrane voltage, structural movements of an ion channel that precede channel opening generate a capacitative gating current. The net gating charge displacement due to membrane depolarization is an index of the voltage sensitivity of the ion channel activation process. Understanding the molecular basis of voltage-dependent gating of ion channels… CONTINUE READING


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