Computing Ka and Ks with a consideration of unequal transitional substitutions

  title={Computing Ka and Ks with a consideration of unequal transitional substitutions},
  author={Zhang Zhang and Jun Li and Jun Jie Yu},
  journal={BMC Evolutionary Biology},
  pages={44 - 44}
Approximate methods for estimating nonsynonymous and synonymous substitution rates (Ka and Ks) among protein-coding sequences have adopted different mutation (substitution) models. In the past two decades, several methods have been proposed but they have not considered unequal transitional substitutions (between the two purines, A and G, or the two pyrimidines, T and C) that become apparent when sequences data to be compared are vast and significantly diverged. We propose a new method (MYN), a… CONTINUE READING
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33(Database issue):D447-53

T Hubbard, D Andrews, +49 authors E Birney
Ensembl • 2005
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