Computer simulation of cytotoxic and vascular effects of radiosurgery in solid and necrotic brain metastases.

@article{Kocher2000ComputerSO,
  title={Computer simulation of cytotoxic and vascular effects of radiosurgery in solid and necrotic brain metastases.},
  author={Martin Kocher and H Treuer and J{\"u}rgen Voges and Moritz Hoevels and Volker J{\"o}rg Friedrich Sturm and Rolf Peter M{\"u}ller},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2000},
  volume={54 2},
  pages={149-56}
}
PURPOSE Solid and necrotic brain tumors respond to radiosurgery, although necrotic lesions often contain a significant proportion of hypoxic cells which cannot become reoxygenated during the short overall treatment time of single dose application. In addition to the direct cytotoxic action, delayed vascular occlusion followed by ischemic tumor cell death could contribute to the effect of radiosurgery. MATERIALS AND METHODS In order to determine the impact of the two possible effects on tumor… CONTINUE READING

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